A REVIEW OF FORMOTEROL-1

TAK-243 preferentially sure to UBA1 over the associated E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased amounts of ubiquitylated proteins, amplified markers of proteotoxic stress and DNA destruction strain. In vivo, TAK-243 lessened leukemic load and specific leukemic stem cells with no proof of toxici